Naive CD4 T cells from aged mice show enhanced death upon primary activation

Poor T cell immunity is one of the many defects seen in elderly humans and aged (Ad) mice. We report that naive CD4 T cells from aged mice (ANCD4 cells) showed greater apoptosis upon primary activation than those from young (Yg) mice, with loss of mitochondrial membrane potential, poor activation of...

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Detalhes bibliográficos
Main Authors: Mattoo, Hamid, Faulkner, Matthew, Kandpal, Usha, Das, Rituparna, Lewis, Virginia, George, Anna, Rath, Satyajit, Durdik, Jeannine M., Bal, Vineeta
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Original Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767129/
https://ncbi.nlm.nih.gov/pubmed/19748905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp094
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