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Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling
Oxidant-liberated intracellular Zn(2+) regulates neuronal apoptosis via an exocytotic membrane insertion of Kv2.1-encoded ion channels, resulting in an enhancement of voltage-gated K(+) currents and a loss of intracellular K(+) that is necessary for caspase-mediated proteolysis. In the present study...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2766646/ https://ncbi.nlm.nih.gov/pubmed/19622611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.176321 |
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