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Parametrization, molecular dynamics simulation and calculation of electron spin resonance spectra of a nitroxide spin label on a poly-alanine alpha helix

The nitroxide spin label 1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl-methanethiosulfonate (MTSSL), commonly used in site-directed spin labeling of proteins, is studied with molecular dynamics (MD) simulations. After developing force field parameters for the nitroxide moiety and the spin label linke...

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Detalhes bibliográficos
Main Authors: Sezer, Deniz, Freed, Jack H., Roux, Benoît
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766176/
https://ncbi.nlm.nih.gov/pubmed/18412413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp711375x
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