Sensitive Detection of KRAS Mutations in Archived Formalin-Fixed Paraffin-Embedded Tissue Using Mutant-Enriched PCR and Reverse-Hybridization

Recently, evidence has emerged indicating that assessment of KRAS mutations before anti-epidermal growth factor receptor therapy improves outcome in patients with metastatic colorectal cancer (CRC). We report here a novel reverse-hybridization (RH) assay to screen for KRAS mutations in formalin-fixe...

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Detalhes bibliográficos
Main Authors: Ausch, Christoph, Buxhofer-Ausch, Veronika, Oberkanins, Christian, Holzer, Barbara, Minai-Pour, Michael, Jahn, Stephan, Dandachi, Nadia, Zeillinger, Robert, Kriegshäuser, Gernot
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Technical Advances
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765748/
https://ncbi.nlm.nih.gov/pubmed/19797612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2009.090022
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