Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve

BACKGROUND AND PURPOSE: Amitriptyline is often prescribed as a first-line treatment for neuropathic pain but its precise mode of analgesic action remains uncertain. Amitriptyline is known to inhibit voltage-dependent ion channels and also to act as an antagonist at ligand-gated ion channels, such as...

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Detalhes bibliográficos
Main Authors: Freysoldt, A, Fleckenstein, J, Lang, PM, Irnich, D, Grafe, P, Carr, RW
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765599/
https://ncbi.nlm.nih.gov/pubmed/19694730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00347.x
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