Response of Staphylococcus aureus to Subinhibitory Concentrations of a Sequence-Selective, DNA Minor Groove Cross-Linking Pyrrolobenzodiazepine Dimer

OBJECTIVES: ELB-21 is a pyrrolo[2,1-c][1,4]benzodiazepine dimer with potent anti-staphylococcal activity; it binds covalently to guanine residues on opposing strands of duplex DNA, interfering with regulatory proteins and transcription elongation in a sequence selective manner. Transcriptional and p...

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Bibliographic Details
Main Authors: Doyle, Marie, Feuerbaum, Eva-Anne, Fox, Keith R., Hinds, Jason, Thurston, David E., Taylor, Peter W.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764867/
https://ncbi.nlm.nih.gov/pubmed/19744983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkp325
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