Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell to proliferate from the plasma membrane to the nucleus. Deregulation of the EGFR/ERK pathway due to alteration...

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Autori principali: Orton, Richard J, Adriaens, Michiel E, Gormand, Amelie, Sturm, Oliver E, Kolch, Walter, Gilbert, David R
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764635/
https://ncbi.nlm.nih.gov/pubmed/19804630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-3-100
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