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Impact of Low-Level Resistance to Fluoroquinolones Due to qnrA1 and qnrS1 Genes or a gyrA Mutation on Ciprofloxacin Bactericidal Activity in a Murine Model of Escherichia coli Urinary Tract Infection

We investigated the impact of low-level resistance to fluoroquinolones on the bactericidal activity of ciprofloxacin in a murine model of urinary tract infection. The susceptible Escherichia coli strain CFT073 (ciprofloxacin MIC [CIP MIC] of 0.008 μg/ml) was compared to its transconjugants harboring...

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Bibliographische Detailangaben
Hauptverfasser: Allou, Nicolas, Cambau, Emmanuelle, Massias, Laurent, Chau, Françoise, Fantin, Bruno
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764221/
https://ncbi.nlm.nih.gov/pubmed/19635960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01664-08
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