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Excitotoxic insults lead to peroxiredoxin hyperoxidation

Post-mitotic neurons must have strong antioxidant defenses to survive the lifespan of the organism. We recently showed that neuronal antioxidant defenses are boosted by synaptic activity. Elevated synaptic activity, acting via the N-methyl-D-aspartate (NMDA) receptor, enhances thioredoxin activity,...

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Detalhes bibliográficos
Main Authors: Léveillé, Frédéric, Soriano, Francesc X, Papadia, Sofia, Hardingham, Giles E
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763254/
https://ncbi.nlm.nih.gov/pubmed/20357934
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