Directed evolution of a (βα)(8)-barrel enzyme to catalyze related reactions in two different metabolic pathways

Enzymes participating in different metabolic pathways often have similar catalytic mechanisms and structures, suggesting their evolution from a common ancestral precursor enzyme. We sought to create a precursor-like enzyme for N′-[(5′-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucl...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Jürgens, Catharina, Strom, Alexander, Wegener, Dennis, Hettwer, Stefan, Wilmanns, Matthias, Sterner, Reinhard
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2000
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27628/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10944186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160255397
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