Directed evolution of a (βα)(8)-barrel enzyme to catalyze related reactions in two different metabolic pathways
Enzymes participating in different metabolic pathways often have similar catalytic mechanisms and structures, suggesting their evolution from a common ancestral precursor enzyme. We sought to create a precursor-like enzyme for N′-[(5′-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucl...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27628/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10944186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160255397 |
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