Directed evolution of a (βα)(8)-barrel enzyme to catalyze related reactions in two different metabolic pathways

Enzymes participating in different metabolic pathways often have similar catalytic mechanisms and structures, suggesting their evolution from a common ancestral precursor enzyme. We sought to create a precursor-like enzyme for N′-[(5′-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucl...

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Bibliografski detalji
Glavni autori: Jürgens, Catharina, Strom, Alexander, Wegener, Dennis, Hettwer, Stefan, Wilmanns, Matthias, Sterner, Reinhard
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC27628/
https://ncbi.nlm.nih.gov/pubmed/10944186
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