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Assessment of Metabolome Annotation Quality: A Method for Evaluating the False Discovery Rate of Elemental Composition Searches

BACKGROUND: In metabolomics researches using mass spectrometry (MS), systematic searching of high-resolution mass data against compound databases is often the first step of metabolite annotation to determine elemental compositions possessing similar theoretical mass numbers. However, incorrect hits...

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Autors principals: Matsuda, Fumio, Shinbo, Yoko, Oikawa, Akira, Hirai, Masami Yokota, Fiehn, Oliver, Kanaya, Shigehiko, Saito, Kazuki
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761541/
https://ncbi.nlm.nih.gov/pubmed/19847304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007490
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