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Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival

Parathyroid hormone-related protein (PTHrP) is expressed by human colon cancer tissue and cell lines; expression correlates with colon carcinoma severity. PTHrP is synthesized as a prepro isoform and contains two targeting sequences – a signal sequence and a nuclear localization signal (NLS). The si...

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Main Authors: Bhatia, V., Saini, M. K., Falzon, M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761501/
https://ncbi.nlm.nih.gov/pubmed/19616583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.regpep.2009.07.008
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