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Chronic Estradiol Replacement Impairs Performance on an Operant Delayed Spatial Alternation Task in Young, Middle-aged, and Old Rats

The current study examined effects of chronic estradiol replacement on a prefrontally-mediated working memory task at different ages in a rodent model. Ovariectomized young, middle-aged, and old Long-Evans rats were given 5% or 10% 17β estradiol in cholesterol vehicle via Silastic implants and teste...

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Detalhes bibliográficos
Main Authors: Wang, Victor C., Neese, Steven L., Korol, Donna L., Schantz, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761498/
https://ncbi.nlm.nih.gov/pubmed/19631212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yhbeh.2009.07.005
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