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Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance

BACKGROUND: Sporadic Parkinson's disease (sPD) is a nervous system-wide disease that presents with a bradykinetic movement disorder and is frequently complicated by depression and cognitive impairment. sPD likely has multiple interacting causes that include increased oxidative stress damage to...

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Bibliografiset tiedot
Päätekijät: Arthur, Charles R, Morton, Stephanie L, Dunham, Lisa D, Keeney, Paula M, Bennett, James P
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761382/
https://ncbi.nlm.nih.gov/pubmed/19775436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-37
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