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Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism

AIMS: Atrial natriuretic peptide (ANP) is a hormone that has both antihypertrophic and antifibrotic properties in the heart. We hypothesized that myocyte-derived ANP inhibits endothelin (ET) gene expression in fibroblasts. METHODS AND RESULTS: We have investigated the mechanism(s) involved in the an...

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Main Authors: Glenn, Denis J., Rahmutula, Dolkun, Nishimoto, Minobu, Liang, Faquan, Gardner, David G.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761198/
https://ncbi.nlm.nih.gov/pubmed/19546173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp208
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