r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans

OBJECTIVE: Leptin is an adipocyte secreted hormone and an important regulator of neuroendocrine, metabolic, and immune function. Both r-metHuLeptin and IGF1 administration result in reduced central adipose tissue in subjects with highly active antiretroviral therapy-induced metabolic syndrome (HAART...

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Main Authors: Brennan, Aoife M., Lee, Jennifer H., Tsiodras, Sotirios, Chan, Jean L., Doweiko, John, Chimienti, Sonia N., Wadhwa, Sanjivini G., Karchmer, Adolf W., Mantzoros, Christos S.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760959/
https://ncbi.nlm.nih.gov/pubmed/19029226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EJE-08-0597
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