No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer

BACKGROUND: Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also known to act as tumour suppressor genes. Increased succinate or fumarate levels as a consequence of SDH and FH deficiency inhibit hypoxia inducible factor-1α (HIF-1α) prolyl...

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Bibliografske podrobnosti
Main Authors: Huang, Katie T, Dobrovic, Alexander, Fox, Stephen B
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Short Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760567/
https://ncbi.nlm.nih.gov/pubmed/19778456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-2-194
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