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SH3BP2 is an activator of NFAT Activity and Osteoclastogenesis
Heterozygous activating mutations in exon 9 of SH3BP2 have been found in most patients with cherubism, an unusual genetic syndrome characterized by excessive remodeling of the mandible and maxilla due to spontaneous and excessive osteoclastic bone resorption. Osteoclasts differentiate after binding...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760267/ https://ncbi.nlm.nih.gov/pubmed/18440306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.04.080 |
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