Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells.

In 1321N1 astrocytoma cells, thrombin, but not carbachol, induces AP-1-mediated gene expression and DNA synthesis. To understand the divergent effects of these G protein-coupled receptor agonists on cellular responses, we examined Gq-dependent signaling events induced by thrombin receptor and muscar...

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Detalhes bibliográficos
Main Authors: Post, G R, Collins, L R, Kennedy, E D, Moskowitz, S A, Aragay, A M, Goldstein, D, Brown, J H
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC276018/
https://ncbi.nlm.nih.gov/pubmed/8930892
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