Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy

BACKGROUND: Thymidylate synthase (TS) and Topoisomerase I (Topo I) are significant biomarkers in colorectal cancer (CRC). We aimed to study the expression of TS and Topo I in patients with resected CRC who received adjuvant chemotherapy and correlated it with clinical outcome. METHODS: All patients...

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Détails bibliographiques
Auteurs principaux: Kostopoulos, Ioannis, Karavasilis, Vasilios, Karina, Maria, Bobos, Mattheos, Xiros, Nikolaos, Pentheroudakis, George, Kafiri, Georgia, Papakostas, Pavlos, Vrettou, Eleni, Fountzilas, George
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759966/
https://ncbi.nlm.nih.gov/pubmed/19775480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-339
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