Antibodies to variant surface antigens of Plasmodium falciparum infected erythrocytes associated with protection from treatment failure and development of anaemia in pregnancy

BACKGROUND: In pregnancy associated malaria (PAM), Plasmodium falciparum infected erythrocytes (IEs) express variant surface antigens (VSA-PAM) that evade existing immunity and mediate placental sequestration. Antibodies to VSA-PAM develop with gravidity and block placental adhesion or opsonise IEs...

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Autors principals: Feng, Gaoqian, Aitken, Elizabeth, Yosaatmadja, Francisca, Kalilani, Linda, Meshnick, Steven R, Jaworowski, Anthony, Simpson, Julie A, Rogerson, Stephen J
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759893/
https://ncbi.nlm.nih.gov/pubmed/19500037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/599841
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