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Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.

Mitotic cyclins are abruptly degraded at the end of mitosis by a cell-cycle-regulated ubiquitin-dependent proteolytic system. To understand how cyclin is recognized for ubiquitin conjugation, we have performed a mutagenic analysis of the destruction signal of mitotic cyclins. We demonstrate that an...

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Hlavní autoři: King, R W, Glotzer, M, Kirschner, M W
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC275986/
https://ncbi.nlm.nih.gov/pubmed/8885231
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