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Perturbation-Response Scanning Reveals Ligand Entry-Exit Mechanisms of Ferric Binding Protein
We study apo and holo forms of the bacterial ferric binding protein (FBP) which exhibits the so-called ferric transport dilemma: it uptakes iron from the host with remarkable affinity, yet releases it with ease in the cytoplasm for subsequent use. The observations fit the “conformational selection”...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758672/ https://ncbi.nlm.nih.gov/pubmed/19851447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000544 |
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