Recognition Versus Adaptive Up-regulation and Degradation of CC Chemokines by the Chemokine Decoy Receptor D6 Are Determined by Their N-terminal Sequence

The chemokine decoy receptor D6 controls inflammatory responses by selective recognition and degradation of most CCR1 to CCR5 agonistic ligands. CCL14 is a homeostatic chemokine present at high concentrations in the serum with a weak agonist activity on CCR1. Under inflammatory conditions, plasmin a...

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Main Authors: Savino, Benedetta, Borroni, Elena Monica, Torres, Nina Machado, Proost, Paul, Struyf, Sofie, Mortier, Anneleen, Mantovani, Alberto, Locati, Massimo, Bonecchi, Raffaella
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758019/
https://ncbi.nlm.nih.gov/pubmed/19632987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029249
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