Anionic Pulmonary Surfactant Phospholipids Inhibit Inflammatory Responses from Alveolar Macrophages and U937 Cells by Binding the Lipopolysaccharide-interacting Proteins CD14 and MD-2

Lipopolysaccharide (LPS), derived from Gram-negative bacteria, is a major cause of acute lung injury and respiratory distress syndrome. Pulmonary surfactant is secreted as a complex mixture of lipids and proteins onto the alveolar surface of the lung. Surfactant phospholipids are essential in reduci...

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Main Authors: Kuronuma, Koji, Mitsuzawa, Hiroaki, Takeda, Katsuyuki, Nishitani, Chiaki, Chan, Edward D., Kuroki, Yoshio, Nakamura, Mari, Voelker, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757950/
https://ncbi.nlm.nih.gov/pubmed/19584052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.040832
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