Genome-wide association study identifies five novel susceptibility loci for Crohn's disease and implicates a role for autophagy in disease pathogenesis.

We present a genome-wide association study of ileal Crohn's disease (CD) and two independent replication studies that identify five novel regions of association to CD. Specifically, in addition to the previously established CARD15 and IL23R associations, we report strong associations with indep...

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Main Authors: Rioux, John D., Xavier, Ramnik J., Taylor, Kent D., Silverberg, Mark S., Goyette, Philippe, Huett, Alan, Green, Todd, Kuballa, Petric, Barmada, M. Michael, Datta, Lisa Wu, Shugart, Yin Yao, Griffiths, Anne M., Targan, Stephan R., Ippoliti, Andrew F., Bernard, Edmond-Jean, Mei, Ling, Nicolae, Dan L., Regueiro, Miguel, Schumm, L. Philip, Steinhart, A. Hillary, Rotter, Jerome I., Duerr, Richard H., Cho, Judy H., Daly, Mark J., Brant, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757939/
https://ncbi.nlm.nih.gov/pubmed/17435756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng2032
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