The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

T helper cells secreting interleukin (IL)-17 (Th17 cells) play a crucial role in autoimmune diseases like multiple sclerosis (MS). Th17 differentiation, which is induced by a combination of transforming growth factor (TGF)-β/IL-6 or IL-21, requires expression of the transcription factor retinoic aci...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Klotz, Luisa, Burgdorf, Sven, Dani, Indra, Saijo, Kaoru, Flossdorf, Juliane, Hucke, Stephanie, Alferink, Judith, Novak, Natalija, Beyer, Marc, Mayer, Gunter, Langhans, Birgit, Klockgether, Thomas, Waisman, Ari, Eberl, Gerard, Schultze, Joachim, Famulok, Michael, Kolanus, Waldemar, Glass, Christopher, Kurts, Christian, Knolle, Percy A.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2009
Предметы:
Brief Definitive Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757877/
https://ncbi.nlm.nih.gov/pubmed/19737866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082771
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы