The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients

BACKGROUND AND PURPOSE: Adding spironolactone to standard therapy in heart failure reduces morbidity and mortality, but the underlying mechanisms are not fully understood. We analysed the effect of canrenone, the major active metabolite of spironolactone, on myocardial contractility and intracellula...

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Bibliografiske detaljer
Main Authors: Costa, AR, Torres, LB, Medei, E, Ricardo, RA, França, JP, Smaili, S, Nascimento, JHM, Oshiro, MEM, Bassani, JWM, Ferreira, AT, Tucci, PJF
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2009
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757698/
https://ncbi.nlm.nih.gov/pubmed/19663883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00329.x
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