Proof-of-concept study on the suitability of (13)C-urea as a marker substance for assessment of in vivo behaviour of oral colon-targeted dosage forms

BACKGROUND AND PURPOSE: (13)C-urea may be a suitable marker to assess the in vivo fate of colon-targeted dosage forms given by mouth. We postulated that release in the colon (urease-rich segment) of (13)C-urea from colon-targeted capsules would lead to fermentation of (13)C-urea by bacterial ureases...

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Detalhes bibliográficos
Main Authors: Schellekens, RCA, Olsder, GG, Langenberg, SMCH, Boer, T, Woerdenbag, HJ, Frijlink, HW, Kosterink, JGW, Stellaard, F
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757693/
https://ncbi.nlm.nih.gov/pubmed/19732063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00302.x
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