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Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity

Thyroid peroxidase (TPO) is the key enzyme in thyroid hormone production and a universal autoantigen in Graves’ and other autoimmune thyroid diseases. We wished to explore the expression of TPO and whether it was affected by thionamide antithyroid drugs. We studied recombinant TPO, stably expressed...

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Detalhes bibliográficos
Main Authors: McDonald, David O., Pearce, Simon H. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757584/
https://ncbi.nlm.nih.gov/pubmed/19669106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-009-0511-y
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