Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase
Guanylyl cyclases (GCs) and adenylyl cyclases (ACs) have fundamental roles in a wide range of cellular processes. Whereas GCs use GTP as a substrate to form cGMP, ACs catalyze the analogous conversion of ATP to cAMP. Previously, a model based on the structure of adenylate cyclase was used to predict...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27573/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.5993 |
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