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Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p
When cells are subjected to nutritional stress, uncharged tRNAs accumulate and activate Gcn2p phosphorylation of eukaryotic initiation factor-2 (eIF2) and the general amino acid control pathway. The Gcn2p regulatory domain homologous to histidyl-tRNA synthetases is proposed to bind to uncharged tRNA...
Tallennettuna:
| Päätekijät: | , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757228/ https://ncbi.nlm.nih.gov/pubmed/19546227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000877 |
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