Kruppel-like Factor KLF10 Targets Transforming Growth Factor-β1 to Regulate CD4(+)CD25(−) T Cells and T Regulatory Cells

CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although the mechanisms controlling T reg development and suppressor function remain incompletely understood. Herein, we provide evidence that Kruppel-like factor 10 (KLF10/TIEG1)...

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Auteurs principaux: Cao, Zhuoxiao, Wara, Akm Khyrul, Icli, Basak, Sun, Xinghui, Packard, René R. S., Esen, Fehim, Stapleton, Christopher J., Subramaniam, Malayannan, Kretschmer, Karsten, Apostolou, Irina, von Boehmer, Harald, Hansson, Göran K., Spelsberg, Thomas C., Libby, Peter, Feinberg, Mark W.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Mechanisms of Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757194/
https://ncbi.nlm.nih.gov/pubmed/19602726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000059
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