Endogenous Human CaMKII Inhibitory Protein Suppresses Tumor Growth by Inducing Cell Cycle Arrest and Apoptosis through Down-regulation of the Phosphatidylinositide 3-Kinase/Akt/HDM2 Pathway

Inhibition of calcium/calmodulin-dependent protein kinase II (CaMKII) results in hypophosphorylation of CaMKII substrates and in some cases suppresses cell growth. We previously presented the first report of the human CaMKII inhibitory protein, hCaMKIINβ. Here we report the functional characterizati...

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Bibliografiska uppgifter
Huvudupphovsmän: Ma, Shenglin, Yang, Yunshan, Wang, Chunmei, Hui, Ning, Gu, Linhui, Zhong, Haijun, Cai, Zhijian, Wang, Qingqing, Zhang, Qinghua, Li, Nan, Cao, Xuetao
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Mechanisms of Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757181/
https://ncbi.nlm.nih.gov/pubmed/19586909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028621
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