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A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis

General base catalysis supplied by the histidine-12 (H-12) residue of ribonuclease (RNase) A has long been appreciated as a major component of the catalytic power of the enzyme. In an attempt to harness the catalytic power of a general base into antibody catalysis of phosphodiester bond hydrolysis,...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wentworth, Paul, Liu, Yunqi, Wentworth, Anita D., Fan, Ping, Foley, Matthew J., Janda, Kim D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27569/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600901/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.5971
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