Structural Insights Into the Activity of Transcriptional Enhancer-Binding Proteins: The structure of an activator protein in complex with an RNA polymerase subunit suggests how ATP hydrolysis is coupled to conformational changes that activate transcription in bacteria

Activators of bacterial σ(54)-RNA polymerase holoenzyme are mechanochemical proteins that use ATP hydrolysis to activate transcription. We have determined a 20 Å resolution structure of an activator, PspF((1-275)), bound to an ATP transition state analog (ADP.AlF(x)), in complex with its basal facto...

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Detalhes bibliográficos
Main Authors: Rappas, Mathieu, Schumacher, Jorg, Beuron, Fabienne, Niwa, Hajime, Bordes, Patricia, Wigneshweraraj, Sivaramesh, Keetch, Catherine A, Robinson, Carol V, Buck, Martin, Zhang, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756573/
https://ncbi.nlm.nih.gov/pubmed/15790859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1105932
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