Vaccination with Mage-b DNA induces CD8 T-cell responses at young but not old age in mice with metastatic breast cancer

BACKGROUND: Elderly individuals react less efficiently to vaccines than do adults, mainly because of T-cell unresponsiveness. In this study, we analysed whether tumour-associated antigen (TAA)-specific CD8 T-cell responses could be induced by vaccination in old mice with metastatic breast cancer. ME...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Castro, F, Leal, B, Denny, A, Bahar, R, Lampkin, S, Reddick, R, Lu, S, Gravekamp, C
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2009
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756562/
https://ncbi.nlm.nih.gov/pubmed/19826426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605329
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