A Small Molecule Polyamine Oxidase Inhibitor Blocks Androgen-Induced Oxidative Stress and Delays Prostate Cancer Progression in the TRAMP Mouse Model

High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiological factor in prostate cancer (CaP) occurrence, recurrence and progression. Androgen induces ROS production in the prostate by a yet unknown mechanism. Here, to the best of our knowledge, we rep...

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Main Authors: Basu, Hirak S., Thompson, Todd A., Church, Dawn R., Clower, Cynthia C., Mehraein-Ghomi, Farideh, Amlong, Corey A., Martin, Christopher T., Woster, Patrick M., Lindstrom, Mary J., Wilding, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756327/
https://ncbi.nlm.nih.gov/pubmed/19773450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2472
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