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Atypical Protein Kinase Cι is Required for Bronchioalveolar Stem Cell Expansion and Lung Tumorigenesis

Protein kinase Cι (PKCι) is an oncogene required for maintenance of the transformed phenotype of non-small cell lung cancer (NSCLC) cells. However, the role of PKCι in lung tumor development has not been investigated. To address this question, we established a mouse model in which oncogenic Kras(G12...

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Main Authors: Regala, Roderick P., Davis, Rebecca K., Kunz, Alyssa, Khoor, Andras, Leitges, Michael, Fields, Alan P.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756303/
https://ncbi.nlm.nih.gov/pubmed/19738040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2066
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