S-Glutathionylation of the Rpn2 Regulatory Subunit Inhibits 26 S Proteasomal Function

Although increased intracellular concentrations of hydrogen peroxide (H(2)O(2)) are associated with inhibition of 26 S proteasomal activity, the mechanisms responsible for such effects have not been well delineated. In the present studies, we found that direct exposure of purified 26 S proteasomes t...

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Bibliographic Details
Main Authors: Zmijewski, Jaroslaw W., Banerjee, Sami, Abraham, Edward
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755946/
https://ncbi.nlm.nih.gov/pubmed/19549781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028902
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