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Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase SoxB

SoxB is an essential component of the bacterial Sox sulfur oxidation pathway. SoxB contains a di-manganese(II) site and is proposed to catalyze the release of sulfate from a protein-bound cysteine S-thiosulfonate. A direct assay for SoxB activity is described. The structure of recombinant Thermus th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sauvé, Véronique, Roversi, Pietro, Leath, Kirstin J., Garman, Elspeth F., Antrobus, Robin, Lea, Susan M., Berks, Ben C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755893/
https://ncbi.nlm.nih.gov/pubmed/19535341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002709
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