Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin

Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force. Here we performed experiments to elucidate the molecular mechanisms for these effe...

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Detalhes bibliográficos
Main Authors: Albet-Torres, Nuria, Bloemink, Marieke J., Barman, Tom, Candau, Robin, Frölander, Kerstin, Geeves, Michael A., Golker, Kerstin, Herrmann, Christian, Lionne, Corinne, Piperio, Claudia, Schmitz, Stephan, Veigel, Claudia, Månsson, Alf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755700/
https://ncbi.nlm.nih.gov/pubmed/19520847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.019232
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