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Human let-7 stem–loop precursors harbor features of RNase III cleavage products
The bidentate RNase III Dicer cleaves microRNA precursors to generate the 21–23 nt long mature RNAs. These precursors are 60–80 nt long, they fold into a characteristic stem–loop structure and they are generated by an unknown mechanism. To gain insights into the biogenesis of microRNAs, we have char...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC275551/ https://ncbi.nlm.nih.gov/pubmed/14602919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg855 |
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