Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest

Although it is established that cAMP accumulation plays a pivotal role in preventing meiotic resumption in mammalian oocytes, the mechanisms controlling cAMP levels in the female gamete have remained elusive. Both production of cAMP via GPCRs/Gs/adenylyl cyclases endogenous to the oocyte as well as...

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Hlavní autoři: Vaccari, Sergio, Horner, Kathleen, Mehlmann, Lisa M., Conti, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755085/
https://ncbi.nlm.nih.gov/pubmed/18280465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.01.018
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