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A simple, convenient method to synthesize cobalamins: synthesis of homocysteinylcobalamin, N -acetylcysteinylcobalamin, 2-N -acetylamino-2-carbomethoxyethanethiolatocobalamin, sulfitocobalamin and nitrocobalamin

Glutathionylcobalamin, nitrocobalamin and sulfitocobalamin are important cobalamin metabolites isolable from human tissues. Herein we demonstrate that a procedure used to synthesize and isolate γ-glutamylcysteinylcobalamin and glutathionylcobalamin in aqueous solution in high yield and purity can be...

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Detalhes bibliográficos
Main Authors: Suarez-Moreira, Edward, Hannibal, Luciana, Smith, Clyde A., Chavez, Roberto A., Jacobsen, Donald W., Brasch, Nicola E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754772/
https://ncbi.nlm.nih.gov/pubmed/17088966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b610158e
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