Insulin Receptor Substrate-2 in β-Cells Decreases Diabetes in Nonobese Diabetic Mice

Insulin receptor substrate-2 (Irs2) integrates insulin-like signals with glucose and cAMP agonists to regulate β-cell growth, function, and survival. This study investigated whether increased Irs2 concentration in β-cells could reduce β-cell destruction and the incidence of type 1 diabetes in nonobe...

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Huvudupphovsmän: Norquay, Lisa D., D'Aquino, Katharine E., Opare-Addo, Lynn M., Kuznetsova, Alexandra, Haas, Michael, Bluestone, Jeffrey A., White, Morris F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Endocrine Society 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754683/
https://ncbi.nlm.nih.gov/pubmed/19574401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0395
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