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Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles
Effective oral delivery of a non-viral gene carrier would represent a novel and attractive strategy for therapeutic gene transfer. To evaluate the potential of this approach, we studied the oral gene delivery efficacy of DNA polyplexes composed of chitosan and Factor VIII DNA. Transgene DNA was dete...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754405/ https://ncbi.nlm.nih.gov/pubmed/18634839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2008.06.019 |
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