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Thymine-rich single-stranded DNA activates Mcm4/6/7 helicase on Y-fork and bubble-like substrates

The presence of multiple clusters of runs of asymmetric adenine or thymine is a feature commonly found in eukaryotic replication origins. Here we report that the helicase and ATPase activities of the mammalian Mcm4/6/7 complex are activated specifically by thymine stretches. The Mcm helicase is spec...

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Autori principali: You, Zhiying, Ishimi, Yukio, Mizuno, Takeshi, Sugasawa, Kaoru, Hanaoka, Fumio, Masai, Hisao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC275434/
https://ncbi.nlm.nih.gov/pubmed/14609960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg576
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