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Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes
High copy number and random segregation confound genetic analysis of the mitochondrial genome. We developed an efficient selection for heritable mitochondrial genome (mtDNA) mutations in Drosophila, thereby enhancing a metazoan model for study of mitochondrial genetics and mutations causing human mi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754248/ https://ncbi.nlm.nih.gov/pubmed/18653897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1160226 |
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