Biased Agonist Pharmacochaperones of the AVP V2 Receptor May Treat Congenital Nephrogenic Diabetes Insipidus

X-linked congenital nephrogenic diabetes insipidus (cNDI) results from inactivating mutations of the human arginine vasopressin (AVP) V2 receptor (hV(2)R). Most of these mutations lead to intracellular retention of the hV(2)R, preventing its interaction with AVP and thereby limiting water reabsorpti...

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Autores principales: Jean-Alphonse, Frédéric, Perkovska, Sanja, Frantz, Marie-Céline, Durroux, Thierry, Méjean, Catherine, Morin, Denis, Loison, Stéphanie, Bonnet, Dominique, Hibert, Marcel, Mouillac, Bernard, Mendre, Christiane
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2009
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754097/
https://ncbi.nlm.nih.gov/pubmed/19729439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008121289
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